Today is World Suicide Prevention Day

…and I want to share something.

A year ago, I attempted to take my own life. Looking back, I can’t really say the exact reason or the events that lead to it, but I can remember the immense sense of relief as I fell asleep.

I’m still here. But one of my closest friends growing up isn’t. I can’t think of the reasons, or the events that lead him to do it. I just know that I’m still confused, and that I still love him.

I don’t know if I could’ve asked him if he was OK more, and I don’t know if I’ve asked the friends that I do have that enough either.

This year’s been pretty fantastic, but even if it wasn’t I’m glad I was here to experience it. I hope by speaking out someone I know, who feels sadness, pain, confusion…who thinks maybe they can’t do it anymore, or that it’d be easier to feel nothing at all, reaches out to me, to a friend, a family member, even a pet. And I hope if that person reaches out to you, you give them that small moment and some kindness.

My Abyssinian Oil Samples Arrived!

Been waiting on these for a while now. I’ll explain why I’m excited…

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Abyssinian oil comes from the seeds of the Crambe Abyssinica, a plant native to the Mediterranean. While its use in cosmetics and hair care is relatively new, it’s been used in industry and manufacturing for decades.

When spread on to the skin or hair the oil spreads quickly, has a drier, less tacky feel, and a thinner texture. This is in part because of its high erucic acid content.

Erucic acid is removed from oils destined for consumption, but topically it has a unique skin feel and presents no dangers. The fatty acid also polymerizes slightly, allowing it to create a film on the surface of the skin or hair. It’s also more stable than other unsaturated fatty acids, because the double bond isn’t conjugated.

The Holy Grail of many vegetable oils and lipids is to mimic the skin feel of silicone. More and more consumers are turning away from synthetic silicones like dimethicone, and we are learning of more risks associated with cyclic silicones, like cyclopentasiloxane.

Many of these natural alternatives still can’t compare to the smoothness, spreadability, and powdery touch of silicone, but honestly I think they’re close enough. I’ve been very impressed by some of the extracts that are being produced from seaweed as well.

AMA: Mark Blaskovich of the Community for Open Antimicrobial Drug Discovery

Artwork by Klari Reis, A Daily Dish

The Community for Open Antimicrobial Drug Discovery was created in 2015 to reach out to chemists, scientists, and researchers to consider screening novel compounds for antibiotic activity.

Drug resistance due to overreliance on a few antibiotics has created strains of bacteria that are becoming more and more difficult to treat.

Think of bacterial resistance like never eating red gummies. With each gummies box your stockpile of red gummies grows larger and larger. But you love gummies, so you keep eating them, and in years of time your kitchen..then your house, is packed to the brim with red gummies. You’ll need a friend who can stomach red gummies to help you. For the sake of the analogy, let’s pretend you can’t just throw the gummies out!

Bacterial resistance is similar, antibiotics target a mechanism that prevents the bacteria from surviving. Due to random mutations some bacteria don’t have this mechanism, or are unaffected by it. As the antibiotic is used more and more the mutated bacteria that are unaffected grow in population, eventually creating strains of these bacteria that the antibiotic no longer works against.

Read his AMA.

Artwork by Klari Reis, A Daily Dish

Mark Blaskovich is also a researcher and scientist, and has worked on a new class of anti-acne drugs that work to reduce activity of the melanocortin-5 receptor, which they found suppresses sebum production when applied to the skin.

Phase II clinical trials for this new anti-acne medication are currently looking for applicants, if you’re in the US, willing to be part of an experiment, have had difficulty with other acne treatments, and are comfortable with the risks of a new drug trial – this may be of interest to you!

ClinicalTrials.gov: A Study to Determine the Efficacy of Topically Applied MTC896 Gel in Subjects With Acne Vulgaris

If this new drug works, and is safe, we may hopefully reduce the reliance on antibiotics for treating acne – which is also contributing to bacterial resistance.